lgRNA
for precise editing
l2gRNA
for scalable precise editing
l-pegRNA/l-epegRNA
ultrapure long guides
Conjugates
for cell-targeting and improved nuclear uptake
Elevate Your Research with Our Guides
Discover our high-quality guide RNAs and conjugates designed for cutting-edge genetic research and clinical applications. Experience unmatched potency and scalability for your projects.
Our lgRNA is synthesized using a segmented approach. The crRNA oligonucleotide segment, 32 nucleotides (nt) long, is produced with high purity via standard phosphoramidite chemistry, achieving high yields (e.g., 53% overall yield at an average 98% stepwise coupling efficiency) even on low-end instruments due to the short synthesis length. This significantly outperforms the theoretical 13.5% yield for a 100 nt sgRNA, which demands a challenging-to-maintain 98% stepwise coupling efficiency for long synthesis and is restricted to gram-scale deliveries in industry. N-1 impurities in a 32mer are easily removed by preparative HPLC or denaturing PAGE, unlike sgRNA, where N-1 impurities remain persistently difficult to decrease. All lgRNA segments are shorter than 36 nt, ensuring compatibility with industrial oligonucleotide manufacturing at kilogram batch scales. Proprietary supports, synthetic intermediates, and robust ligation protocols have been developed to optimize synthesis efficiency and scalability.
About Our Company
★★★★★
At our company (part of GeneLancet), we specialize in providing high-quality guide RNAs and conjugates that are essential for advancing genetic research and clinical development. Our products are designed to meet the rigorous demands of the biotechnology and pharmaceutical industries, ensuring that researchers have access to potent and scalable solutions. We pride ourselves on our commitment to innovation, offering chemically ligated guides that are compatible with various modifications. Our guide RNA conjugates can be tailored to include peptides, small molecular ligands, lipids, and PEGs, allowing for flexibility in research applications. With a focus on quality and reliability, we aim to support scientists in their quest for breakthroughs in molecular biology. Our guide RNAs are strictly for research use only (RUO), ensuring compliance with industry standards.
Key Advantages
+ High-quality, potent guide RNAs for effective research
+ Scalable production for clinical development needs
+ Customizable guide RNA conjugates for diverse applications
Potential Limitations
– Products are for research use only, not for clinical use
– Limited availability upon request