Denaturing PAGE is superior to chromatographic methods in separation of long guide RNAs. Our products are purified by denaturing PAGE, and gel images are included in shipping packages. LC-MS analysis data of ALL segments are included upon request with additional costs.
All products are terminally modified with 2′-methoxyl phosphorothioates at 5′- and 3′-ends. Please contact us for our high-potent guides with proprietary modifications.
We are also available for custom synthesis of ligated guides with your selected modifications. Please contact us for quotes.
Long guides (99-119nt), single ligation:
<10 nmol $ 695 (TAT: 7 days)
20 nmol $ 1390 (TAT: 15 days)
50 nmol $ 3450 (TAT: 30 days)
Ultra-long guides (99-220nt), 2-3 ligations:
200 micrograms $ 6,995 (TAT: 12 days)
500 micrograms $ 15,750 (TAT: 30 days)
1 milligram $ 29,900 (TAT: 60 days)
Ultra-long guides for prime editing (120-220nt), 2-3 ligations:
200 micrograms $ 6,995 (TAT: 12 days)
500 micrograms $ 15,750 (TAT: 30 days)
1 milligram $ 29,900 (TAT: 60 days)
Guide RNA conjugates of lipids, ligands, aptamers, fluorescent dyes and peptides:
Long and ultralong guides only (99-220nt). LC-MS analysis data of ALL segments are included. PAGE images of oligo segments and final products are included. Project reports are included. Prices vary. Contact us.
Ultrapure long CRISPR guides
— For efficient precise crispr
Chemical ligations for efficacy, safety and scalability of CRISPR medicine
Your design, our delivery
— For innovative crispr developers
LgRNA conjugates
Notes:
- For the listed prices, project reports are not included.
- TAT: estimated turnaround time. It may vary among different sequences.
- Ultra-purity guide RNA products (with no detectable N-1 impurities by LC-MS) are available. The product purity is ensured by PAGE purifications of ALL oligo segments. Please contact us.
- Please include guide sequences and amounts in your inquiries. We can also prioritize some special orders.
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