High-Quality, Potent and Scalable
🔬 Elevate Your Research with Our Guide RNAs!
Innovative Guide RNAs
Explore our range of high-quality, potent guide RNAs designed for non-clinical development and research use only: precise (no detectable spacer impurities), precise and scalable (kilogram batches), cell-targeting (conjugates)
Customizable Solutions
Discover our customizable guide RNA conjugates tailored for your specific research needs and applications.
Chemical ligations of oligonucleotides
Proprietary chemical modifications for high potency and high specificity, or your choices
Conjugations of aptamers, ligands, lipids, peptides and fluorescent dyes
LgRNA provides nearly single FLP component products. An example mass spectrum (ESI) by direct injection.
LgRNA can be >30 times more potent than sgRNA (Anti-HBV activities in human hepatocytes).
Single sharp bands on high-resolution denaturing PAGE represent superior quality of our long guides.
Innovative Solutions
Advanced Guide RNA Technologies
Explore our cutting-edge guide RNA technologies designed for high efficiency and scalability in genetic research and non-clinical applications.
Innovative Solutions
Advanced Guide RNA Technologies
Explore our cutting-edge guide RNA technologies designed for high efficiency and scalability in genetic research and non-clinical applications.
What are guide RNAs?
Guide RNAs (gRNAs) are essential components in CRISPR technology, designed to direct the Cas9 enzyme to specific DNA sequences for editing. The specificity is determined by base pairing recognitions of spacer. Spacer impurities can lead to catastrophic off-targets. Our gRNAs are high-quality, potent, and suitable for various research applications, ensuring precise targeting and effective results.
How are your guide RNAs modified?
Our guide RNAs are terminally chemically modified to enhance stability. It is optional to add our proprietary modifications, if high potency and specificity are critical for your projects. These modifications are compatible with additional functionalities, making them versatile for various experimental needs.
What is the scale of your production?
We offer scalable production of guide RNAs, capable of delivering kilogram batches for non-clinical development. This ensures that researchers and developers have access to the quantities they need for their projects.
Are your products for research use only?
Yes, our guide RNAs and conjugates are intended for research use only (RUO). They are not approved for clinical use and should be utilized in accordance with applicable regulations and guidelines.
What is the shelf life of your guide RNAs?
Longer than 6 months when stored at -20 oC. We provide customizable guide RNAs tailored to your specific research requirements. You can choose modifications, conjugates, and other parameters to suit your experimental needs.
What types of conjugates do you offer with guide RNAs?
We offer a variety of guide RNA conjugates, including fluorescent dyes, peptides, aptamers, small molecular ligands, lipids, and PEGs. These conjugates can be positioned at desired locations (besides 5′- and 3′-end) to enhance functionality and targeting in your research.
Need assistance with your order?
We are here to help you with any questions or concerns regarding your order. Our team is dedicated to providing you with the support you need for your research.